Figure 4

Cell cycle distribution from fluorescent-activated cell sorting (FACs) analysis of T-ALL cell lines after treatment with GSK1070916 at 24, 46, and 72 hours. (a) MOLT-16 was sensitive to GSK1070916 and showed increasing amounts of sub-2N DNA (blue) indicating cell death.(b) In contrast, CTV-1 had higher amounts of 4N DNA or greater (light blue, green) which increased with prolonged exposure to GSK1070916, generating a large multinucleated resistant phenotype.