Table 1 Clinicopathological characteristics of the EAC study population (with and without histological proven BE)
Characteristics | Patients (n = 60) | MMP-1 expression EAC | p-value | |
|---|---|---|---|---|
|  |  | Low (<46%) | High (≥ 46%) |  |
Age (y) | Â | Â | Â | .605 |
<66 | 30 (50%) | 13 (43%) | 17 (57%) | Â |
≥66 | 30 (50%) | 14 (47%) | 16 (53%) |  |
Gender | Â | Â | Â | .465 |
Male | 52 (87%) | 24 (46%) | 28 (54%) | Â |
Female | 8 (13%) | 5 (63%) | 3 (37%) | Â |
Histological classification |  |  |  | .032†|
G1 | 17 (28%) | 11 (65%) | 6 (35%) | Â |
G2 | 22 (37%) | 12 (55%) | 10 (45%) | Â |
G3/4 | 21 (33%) | 6 (29%) | 15 (71%) | Â |
Depth of invasion |  |  |  | .163††|
pT1 | 16 (27%) | 9 (56%) | 7 (44%) | Â |
pT2 | 26 (43%) | 14 (54%) | 12 (46%) | Â |
pT3 | 10 (17%) | 3 (30%) | 7 (70%) | Â |
pT4 | 8 (13%) | 3 (38%) | 5 (62%) | Â |
Lymph nodes metastasis | Â | Â | Â | .016 |
pN0 | 23 (38%) | 16 (70%) | 7 (30%) | Â |
pN1-3 | 37 (62%) | 13 (35%) | 24 (65%) | Â |
UICC stage |  |  |  | .163†††|
UICC I | 14 (23%) | 8 (57%) | 6 (43%) | Â |
UICC II | 28 (47%) | 15 (54%) | 13 (46%) | Â |
UICC III | 18 (30%) | 6 (33%) | 12 (67%) | Â |
UICC IV | 0 (0%) | 0 (0%) | 0 (0%) | Â |
Median OS (m) | 43 m | 47 (n = 29) | 38 (n = 31) | Â |