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Table 1 Clinicopathological characteristics of the EAC study population (with and without histological proven BE)

From: MMP-1 is a (pre-)invasive factor in Barrett-associated esophageal adenocarcinomas and is associated with positive lymph node status

Characteristics

Patients (n = 60)

MMP-1 expression EAC

p-value

  

Low (<46%)

High (≥ 46%)

 

Age (y)

   

.605

<66

30 (50%)

13 (43%)

17 (57%)

 

≥66

30 (50%)

14 (47%)

16 (53%)

 

Gender

   

.465

Male

52 (87%)

24 (46%)

28 (54%)

 

Female

8 (13%)

5 (63%)

3 (37%)

 

Histological classification

   

.032

G1

17 (28%)

11 (65%)

6 (35%)

 

G2

22 (37%)

12 (55%)

10 (45%)

 

G3/4

21 (33%)

6 (29%)

15 (71%)

 

Depth of invasion

   

.163††

pT1

16 (27%)

9 (56%)

7 (44%)

 

pT2

26 (43%)

14 (54%)

12 (46%)

 

pT3

10 (17%)

3 (30%)

7 (70%)

 

pT4

8 (13%)

3 (38%)

5 (62%)

 

Lymph nodes metastasis

   

.016

pN0

23 (38%)

16 (70%)

7 (30%)

 

pN1-3

37 (62%)

13 (35%)

24 (65%)

 

UICC stage

   

.163†††

UICC I

14 (23%)

8 (57%)

6 (43%)

 

UICC II

28 (47%)

15 (54%)

13 (46%)

 

UICC III

18 (30%)

6 (33%)

12 (67%)

 

UICC IV

0 (0%)

0 (0%)

0 (0%)

 

Median OS (m)

43 m

47 (n = 29)

38 (n = 31)

 
  1. EAC, esophageal adenocarcinomas; BE, Barrett metaplasia; y, years; G, grading; UICC, International Union against Cancer; R, residual tumor; OS, overall survival; m, months.
  2. G1/2 vs. GT3/4; ††pT1/2 vs. pT3/4; †††UICC I/II vs. UICC III/IV