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Table 1 Clinicopathological characteristics of the EAC study population (with and without histological proven BE)

From: MMP-1 is a (pre-)invasive factor in Barrett-associated esophageal adenocarcinomas and is associated with positive lymph node status

Characteristics Patients (n = 60) MMP-1 expression EAC p-value
   Low (<46%) High (≥ 46%)  
Age (y)     .605
<66 30 (50%) 13 (43%) 17 (57%)  
≥66 30 (50%) 14 (47%) 16 (53%)  
Gender     .465
Male 52 (87%) 24 (46%) 28 (54%)  
Female 8 (13%) 5 (63%) 3 (37%)  
Histological classification     .032
G1 17 (28%) 11 (65%) 6 (35%)  
G2 22 (37%) 12 (55%) 10 (45%)  
G3/4 21 (33%) 6 (29%) 15 (71%)  
Depth of invasion     .163††
pT1 16 (27%) 9 (56%) 7 (44%)  
pT2 26 (43%) 14 (54%) 12 (46%)  
pT3 10 (17%) 3 (30%) 7 (70%)  
pT4 8 (13%) 3 (38%) 5 (62%)  
Lymph nodes metastasis     .016
pN0 23 (38%) 16 (70%) 7 (30%)  
pN1-3 37 (62%) 13 (35%) 24 (65%)  
UICC stage     .163†††
UICC I 14 (23%) 8 (57%) 6 (43%)  
UICC II 28 (47%) 15 (54%) 13 (46%)  
UICC III 18 (30%) 6 (33%) 12 (67%)  
UICC IV 0 (0%) 0 (0%) 0 (0%)  
Median OS (m) 43 m 47 (n = 29) 38 (n = 31)  
  1. EAC, esophageal adenocarcinomas; BE, Barrett metaplasia; y, years; G, grading; UICC, International Union against Cancer; R, residual tumor; OS, overall survival; m, months.
  2. G1/2 vs. GT3/4; ††pT1/2 vs. pT3/4; †††UICC I/II vs. UICC III/IV