Prognostic significance of Oct4 and Sox2 expression in hypopharyngeal squamous cell carcinoma

Table 2 The relationships between clinicopathological variables and immunohistochemical features with the overall survival.

Variables	No. patients	OS (%)			P ^a	χ²
		1 y	3 y	5 y
Age^b (y)
<60	41	65.9	19.5	17.1	0.555	0.348
≥60	44	63.6	25.0	20.5
Histological grade
Well	34	66.7	25.0	25.0	0.996	0.008
Moderately	39	67.6	20.6	17.6
Poorly	12	61.5	23.1	17.9
SCCA^c (ng/ml)
≤ 1	43	69.8	18.6	16.2	0.200	1.639
> 1	21	71.4	19.0	14.3
TSGF^d (ng/ml)
≤ 70	33	69.7	15.2	12.1	0.244	1.356
> 70	22	68.2	22.7	18.2
T Stage
1~2	21	90.5	23.8	14.3	0.303	1.061
3~4	64	56.3	25.0	20.3
Cervical lymph node metastasis
positive	66	63.6	18.2	15.2	0.103	2.662
negative	19	68.4	36.8	31.6
TNM Stage
I~II	7	100	28.5	28.5	0.678	0.173
III~IV	78	61.5	21.8	17.9
Oct4^e
High Expression	14	85.7	71.4	57.1	0.000	15.661
Low Expression	71	60.6	12.7	11.3
Sox2^e
High Expression	67	59.7	23.9	19.4	0.683	0.166
Low Expression	18	83.3	16.7	16.7
Oct4 & Sox2					0.000	17.991
Both high	13	88.2	76.9	61.5
Either high	55	54.5	10.9	9.1
Both low	17	82.4	17.6	17.6

^a Log-rank test
^b Patients were divided according to the median values of age.
^c SCCA, Squamous Cell Carcinoma Antigen
^d TSGF, Tumor Supplied Group of Factor
^e Two-sided log rank test with an overall sample size of 85 subjects (of which 71 are in group
1 and 14 are in group 2) achieves 84% power at a 0.0500 significance level to detect a difference of 0.5870 between 0.1270 and 0.7140--the proportions surviving in groups 1 and 2,respectively. This corresponds to a hazard ratio of 0.1632. These results are based on the assumption that the hazard rates are proportional.

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