Skip to main content

Table 2 The relationships between clinicopathological variables and immunohistochemical features with the overall survival.

From: Prognostic significance of Oct4 and Sox2 expression in hypopharyngeal squamous cell carcinoma

Variables No.
patients
OS (%) P a χ2
   1 y 3 y 5 y   
Ageb (y)       
   <60 41 65.9 19.5 17.1 0.555 0.348
   ≥60 44 63.6 25.0 20.5   
Histological grade      
   Well 34 66.7 25.0 25.0 0.996 0.008
   Moderately 39 67.6 20.6 17.6   
   Poorly 12 61.5 23.1 17.9   
SCCAc (ng/ml)      
   ≤ 1 43 69.8 18.6 16.2 0.200 1.639
   > 1 21 71.4 19.0 14.3   
TSGFd (ng/ml)      
   ≤ 70 33 69.7 15.2 12.1 0.244 1.356
   > 70 22 68.2 22.7 18.2   
T Stage       
   1~2 21 90.5 23.8 14.3 0.303 1.061
   3~4 64 56.3 25.0 20.3   
Cervical lymph
node metastasis
    
   positive 66 63.6 18.2 15.2 0.103 2.662
   negative 19 68.4 36.8 31.6   
TNM Stage       
   I~II 7 100 28.5 28.5 0.678 0.173
   III~IV 78 61.5 21.8 17.9   
Oct4e      
   High Expression 14 85.7 71.4 57.1 0.000 15.661
   Low Expression 71 60.6 12.7 11.3   
Sox2e       
   High Expression 67 59.7 23.9 19.4 0.683 0.166
   Low Expression 18 83.3 16.7 16.7   
Oct4 & Sox2     0.000 17.991
   Both high 13 88.2 76.9 61.5   
   Either high 55 54.5 10.9 9.1   
   Both low 17 82.4 17.6 17.6   
  1. a Log-rank test
  2. b Patients were divided according to the median values of age.
  3. c SCCA, Squamous Cell Carcinoma Antigen
  4. d TSGF, Tumor Supplied Group of Factor
  5. e Two-sided log rank test with an overall sample size of 85 subjects (of which 71 are in group
  6. 1 and 14 are in group 2) achieves 84% power at a 0.0500 significance level to detect a difference of 0.5870 between 0.1270 and 0.7140--the proportions surviving in groups 1 and 2,respectively. This corresponds to a hazard ratio of 0.1632. These results are based on the assumption that the hazard rates are proportional.