S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (P. anubis)

Table 2 Pharmacokinetic data

Parameter	Units	Decitabine Injection (0.5 mg/kg)	S110 injection (1.0 mg/kg)
Compound		Decitabine	S110	Decitabine
HL_LAMBDA_z	min	93	39	58
Tmax	min	30	16	15
Cmax	ng/ml	16	6	17
AUCall	min*ng/ml	1149	397	494
AUCINF_OBS	min*ng/ml	1463	516	593

Pharmacokinetic data calculated for baboons treated with decitabine and S110.
HLLambda z- half life, Tmax- time of maximal drug concentration, Cmax-concentration at Tmax, AUCall-area under the curve from time of dosing to last observation, AUCINF_OBS-area under the curve from time of dosing to infinity.

ISSN: 1479-5876