Figure 2
From: S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (P. anubis)
Comparison of the effects of S110 and decityabine on globin gene expression in cultured human erythroid progenitor cells. A. Effect of decitabine and S110 on expression of γ-globin mRNA in cultured human erythroid progenitor cells. Results are expressed as fold change (± SD) relative to untreated controls. The difference in γ/γ+β mRNA between the untreated controls and drug-treated cultures was significant (p < .05). B. Effect of decitabine and S110 on the γ/γ + β chain ratio in cultured human erythroid progenitor cells. The difference in γ/γ + β chain ratio between the untreated controls and drug-treated cultures was significant (p < .05).