Figure 3

Pools of eosinohilis in the mid and deep layers following the third vaccine. (a) Numerous eosinophils are present in the subcutis. Bar = 200 μm. (b) High-power view. Note the distinctive cytologic detail, including the bilobed nucleus in a round cell with numerous, red cytoplasmic granules. Bar = 20 μm (c) Focal areas of fat necrosis (empty spaces of various sizes) are present. Bar = 200 μm (d) Note sites of vaccine deposits (large, "empty" spaces walled off by macrophages. Bar = 100 μm.