Figure 2
Lymphohistiocytic infiltrate increasing over time. H&E stained histologic sections of replicate vaccination site, representative for each time point (A: no vaccine; B: 1 week after 1st vaccine; C: 1 week after 3rd vaccine; D: 1 week after 6th vaccine; E: 6 weeks after 6th vaccine). Top panel: The three compartments: superficial papillary dermis; middle panel: deep dermis, lower panel: subcutis. Note the significant increase of the inflammatory infiltrate between the first (B) and third (C) vaccination in all compartments. Bar = 100 μm.