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Table 1 Examples of spectral components that differentiated serum samples collected after surgery and one year after the end of basic therapy.

From: Mass spectrometry-based analysis of therapy-related changes in serum proteome patterns of patients with early-stage breast cancer

 

q-value of the difference

Component m/z

Hypothetical identity

Δ

All patients

Adjuvant therapy

Only surgery

2,742

  

0.050

0.118

0.275

3,263

FGA (fr.576-604)

I

0.053

0.084

0.506

3,302

-

I

0.039

0.238

0.150

3,992

-

D

0.039

0.136

0.182

4,038

-

I

0.099

0.099

0.510

4,524

APP (fr.672-713)

D

0.053

0.084

0.462

4,642

-

D

0.049

0.201

0.157

4,713

-

I

0.038

0.199

0.152

5,048

-

I

0.025

0.081

0.262

5,067

-

I

0.038

0.084

0.367

5,377

-

D

0.053

0.016

0.344

5,403

-

D

0.159

0.016

0.181

5,877

FGA (fr.581-633)

D

0.039

0.084

0.238

5,998

-

D

0.076

0.084

0.344

6,489

-

D

0.038

0.084

0.272

6,939

TTR (fr.21-147)

I

0.001

0.016

0.119

8,032

-

D

0.037

0.090

0.193

8,095

-

D

0.038

0.128

0.137

8,156

-

D

0.039

0.201

0.150

8,354

C3 (fr.672-739)

D

0.038

0.238

0.101

8,844

-

D

0.053

0.086

0.251

8,888

VTN (fr.402-478)

D

0.039

0.206

0.152

8,931

C3 (fr.672-747)

D

0.039

0.238

0.106

8,942

APOA2 (fr.24-100)

D

0.024

0.084

0.204

8,973

-

D

0.024

0.099

0.193

9,419

APOC3 (fr.21-99)

I

0.024

0.084

0.207

9,519

-

D

0.039

0.207

0.150

9,990

-

D

0.099

0.081

0.333

12,359

-

D

0.038

0.238

0.151

12,453

-

D

0.048

0.154

0.244

  1. Shown are: approximate m/z value, hypothetical identity, average change in abundance between samples B and C (D - decrease, I - increase) and q-value of the difference (the Storey test). Components that differentiated samples B and C both in group of all patients and patients subjected to adjuvant therapy are underlined.
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Journal of Translational Medicine

ISSN: 1479-5876

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