Figure 2

Comparison of infarct area and sensorimotor function in rats with and without ADMSC treatment. (A & B) Identification of gross infarct area (blue arrows) with and without ADMSC treatment, respectively. (C) Significantly lower ratio of infarct area to total coronal section area in stroke + ADMSC group (group 3) compared with stroke group (group 2) (n = 5 per group). † vs. *, p < 0.001. (D) The results of Corner test on days 0, 3, 7, 14, and 21 after acute IS, showing a steady state of neurological functional impairment on day 3 following acute IS in both group 2 and group 3. Significant improvement in neurological function noted only in group 3 compared with group 2 on day 14 and substantially improved on day 21 after acute IS. Significance of difference at respective time point: * p < 0.005, group 2 vs. group 3; † p < 0.002, group 2 vs. group 3. (E) and (F) Identification of CM-DiI-stained ADMSCs (yellow arrows) in brain infarct area of two rats from group 3. Scale bars in right lower corner represent 50 μm.