Skip to main content

Table 4 Inhibition by Ab-01 of ex vivo rhIL21-dependent IL2RA expression

From: Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood

Animal rHuIL21 alone rHuIL21 + Control IgG1TM rHuIL21 + Ab-01
1 4.7 3.5 1.2
2 3.8 3.8 0.9
3 4.1 5.1 1.4
4 2.8 2.8 0.9
5 3.3 3.2 1.3
6 2.8 2.9 1
7 3.6 3.7 1.1
8 7.2 8.8 1.1
  1. Each value represents the fold change over the no-treatment group in expression levels of IL2RA in monkey blood samples following 4 hour ex vivo treatment as indicated.