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Table 3 rhIL21-responsive genes in whole cynomolgus monkey blood

From: Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood

Gene

Average Fold Change (with IL21)

SD

P-value paired t-test

IL2RA

4.1

1.76

< 0.0001

PRF1

1.8

0.78

<0.0001

IL21R

2.3

0.63

<0.0001

GZMB

1.6

0.39

<0.0001

IL6

2.7

1.72

0.0007

  1. rhIL21-mediated average fold increase in RNA expression in blood of 18 individual cynomolgus monkeys stimulated in vitro for 4 hours. Control (no rhIL21) RNA expression values were normalized to 1, and p values were calculated using log2 of the fold change paired with the log2 of 1 (0).
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Journal of Translational Medicine

ISSN: 1479-5876

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