Figure 6
From: HSF1 overexpression enhances oncolytic effect of replicative adenovirus
The antitumor efficacy of Adel55-cHSF1 on Bcap37 and SW620 xenograft tumors in nude mice. (A) The antitumoral efficacy of Adel55-cHSF1 in nude mice bearing Bcap37 or SW620 xenograft tumors. When tumor volumes reached about 30 mm3, mice were intratumorally injected with PBS or 5×108 PFU of Adel55, Adel55-cHSF1 or Adel55-HSF1i once a day for 2 consecutive days. The tumor volume was measured at 5-day intervals and is presented as means ± SD of eight mice. (B) Titration of virus progeny recovered from tumor xenografts of 20 or 40 days. Extracts were prepared and titrated as described in Materials and Methods. The titer was adjusted to the weight of each tumor and expressed as PFU/g of tissue. Each column represents the mean titer ± SD (n = 3).