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Table 3 Peak and last detectable concentrations, and elimination half-life after a single 10 mg/kg IV dosage of Ab-01 or Ab-02 to cynomolgus monkeys

From: Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys

Group

Animal

Cpeak

(μg/mL)

t1/2

(days)

Clast

(μg/mL)

Tlast

(days)

A (Ab-01)

1

200

12

0.91

50

 

2

139

6.2

0.56

36

 

3

153

14

0.37

71

 

Mean

164

11

0.61

52

 

SD

32

3.9

0.27

18

B (Ab-02)

4

145

2.5

0.36

15

 

5

155

2.3

0.26

15

 

6

201

2.1

0.25

15

 

Mean

167

2.3

0.29

15

 

SD

30

0.16

0.06

0

  1. Cpeak = Concentration at 5 minutes, the first sampling time point after IV administration; t1/2 = elimination half-life; Tlast = last time point at which the test article concentration was above the LOQ (30.0 ng/mL); Clast = concentration at Tlast.
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Journal of Translational Medicine

ISSN: 1479-5876

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