Figure 6
![Figure 6](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2F1479-5876-8-33/MediaObjects/12967_2009_Article_455_Fig6_HTML.jpg)
SERPINE1 mRNA level in fibroblasts under hypoxia. Transfection of miRNA-449a/b inhibitors and miRNA-449a/b mimics targeted SERPINE1 mRNA under hypoxic culture conditions. The mimicking of miRNA-449a/b reversed SERPINE1 mRNA to baseline level. Depicted are calculations relative to reference gene POLR2A compared with non-transfected cells cultured under hypoxia. Negative control means cells transfected with negative control siRNA only. SERPINE1 mRNA induction through hypoxia alone and without additional transfection of miRNA-449 inhibitors or miRNA-449 mimics is indicated by the dotted line (cell line F-18). ** = p < 0.01 (three independent experiments).