Effect of dipterinyl calcium pentahydrate on hepatitis B virus replication in transgenic mice

Table 1 The DCP Effects Model (DCP-EM) was derived from the stepwise regression of the DCP dose versus: serum Tryptophan, Kynurenine, Kyn/Trp; HBV DNA [Southern], HBV DNA [PCR], HBV RNA [PCR], HBe antigen [ELISA]; Average # Liver HBcAg Nuclei per Total, Average # Liver HBcAg Cytoplasms per Total, Average # Liver HBcAg Nuclei per Quarter Field; IL-1a, IL-1b, IL-2, IL-3, IL-4, IL-6, IL-9, IL-10, IL-12, MCP-1, TNF-α, MIP-1, GM-CSF, RANTES, and liver IL-6; log HBV DNA [Southern], log rel. HBV DNA [PCR], log HBV RNA [PCR], and log HBe antigen [ELISA].

Coefficients of variables in cluster modelling DCP dosing effects
	Unstandardized Coefficients		Standardized Coefficients
DCP-EM Model* (variable cluster)	B	Std. Error	Beta	Sig.
(Constant)	26.309	4.976		.000
MCP-1	-.022	.007	-.371	.003
Log HBV DNA (PCR)	-4.065	1.376	-.359	.005
Kyn/Trp	-.560	.196	-.349	.006
GM-CSF	.070	.030	.283	.023

Probability-to-Enter = .10 and Probability-to-Remove = .15. The model is significant to *p = .001.
Derived DCP-EM Regression Model*:
DCP-EM score = 26.309 - 0.22 [MCP-1 rel. pg/ml] - 4.065 [Log rel. HBV DNA (PCR)]
-.560 [Kyn/Trp uM/mM] + 0.070 [GM-CSF rel. pg/ml]

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