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Table 1 5-Fluorouracil (100 mg/kg, i.v.) pharmacokinetics in rats after irradiation with and without 0.5 and 2 Gy.

From: Abdominal irradiation modulates 5-Fluorouracil pharmacokinetics

Parameters

Controls

Whole abdomen irradiation

0 Gy

0.5 Gy

2 Gy

AUC (min μg/mL)

4641 ± 414

3647 ± 726*

3168 ± 270*†

t1/2 (min)

32.3 ± 10

30.3 ± 2.5

26.9 ± 4.0*

Cmax (μg/mL)

160.0 ± 33

131 ± 19

146 ± 27

MRT (min)

36.0 ± 2.7

31 ± 4.2*

25 ± 1.5*†

CL (mL/kg/min)

21.0 ± 1.9

28.5 ± 7.3*

31.7 ± 2.6*†

Vss (mL/kg)

798.0 ± 89

885 ± 96*

824 ± 89*

Kelgo1/minp

0.026 ± 0.001

0.031 ± 0.004

0.037 ± 0.001

  1. AUC: area under the plasma concentration vs. time curve; t1/2: terminal elimination phase half-life; Cmax: maximum observed plasma concentration; MRT: mean residence time; CL: total plasma clearance; Vss: volume of distribution at steady state; Kel: elimination constant.
  2. *The mean difference is significant at the 0.05 level in comparison to the control group.
  3. †The mean difference is significant at the 0.05 level between the 0.5 and 2 Gy groups.
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Journal of Translational Medicine

ISSN: 1479-5876

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