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Table 5 Mirs Significantly Differentially Expressed Between Pediatric And Young Adult Nevus (Nevus 30) Vs Pediatric And Young Adult Melanoma (Mel 30)

From: Microrna profiling analysis of differences between the melanoma of young adults and older adults

Array A Hsa-miR Name-Assay#

FC (NEVUS30/MEL30)

Log2(FC)

p value

FDR (BH)

FC Bin

hsa-miR-886-3p-4395305

0.4464

-1.1637

0.0001

0.0289

FC 2.0-4.0

hsa-miR-449a-4373207

0.2143

-2.2223

0.0006

0.0541

FC > 4

hsa-miR-124-4373295

0.2453

-2.0273

0.0011

0.0541

FC > 4

hsa-miR-382-4373019

0.1211

-3.0453

0.0011

0.0541

FC > 4

hsa-miR-301b-4395503

0.2264

-2.1432

0.0012

0.0541

FC > 4

hsa-miR-363-4378090

0.1417

-2.8193

0.0015

0.0577

FC > 4

hsa-miR-22-4373079

0.1349

-2.8895

0.0019

0.0635

FC > 4

hsa-miR-505-4395200

0.2482

-2.0105

0.0028

0.0749

FC > 4

hsa-miR-135a-4373140

0.3156

-1.6640

0.0031

0.0749

FC 2.0-4.0

hsa-miR-125b-4373148

2.0505

1.0360

0.0032

0.0749

FC 2.0-4.0

hsa-miR-518f-4395499

0.3908

-1.3554

0.0193

0.3107

FC 2.0-4.0

hsa-miR-886-5p-4395304

0.3436

-1.5412

0.0212

0.3107

FC 2.0-4.0

hsa-miR-517c-4373264

0.2671

-1.9043

0.0229

0.3107

FC 2.0-4.0

hsa-miR-31-4395390

0.1841

-2.4418

0.0247

0.3107

FC > 4

hsa-miR-542-3p-4378101

0.4443

-1.1704

0.0251

0.3107

FC 2.0-4.0

hsa-miR-449b-4381011

0.4818

-1.0536

0.0251

0.3107

FC 2.0-4.0

hsa-miR-135b-4395372

0.1699

-2.5570

0.0273

0.3107

FC > 4

hsa-miR-212-4373087

0.3822

-1.3875

0.0279

0.3107

FC 2.0-4.0

hsa-miR-15a-4373123

0.2598

-1.9443

0.0281

0.3107

FC 2.0-4.0

hsa-miR-362-3p-4395228

2.5474

1.3490

0.0301

0.3107

FC 2.0-4.0

hsa-miR-21-4373090

0.3731

-1.4224

0.0302

0.3107

FC 2.0-4.0

hsa-miR-134-4373299

0.4606

-1.1185

0.0305

0.3107

FC 2.0-4.0

hsa-miR-379-4373349

0.5984

-0.7408

0.0318

0.3107

FC 1.6-2.0

hsa-miR-301a-4373064

0.4202

-1.2510

0.0319

0.3107

FC 2.0-4.0

hsa-miR-424-4373201

0.2091

-2.2578

0.0332

0.3107

FC > 4

hsa-miR-548b-5p-4395519

0.5227

-0.9359

0.0382

0.3442

FC 1.6-2.0

hsa-miR-211-4373088

5.3696

2.4248

0.0400

0.3443

FC > 4

hsa-miR-494-4395476

0.2695

-1.8915

0.0412

0.3443

FC 2.0-4.0

hsa-miR-519a-4395526

0.4132

-1.2752

0.0458

0.3697

FC 2.0-4.0

Array B Hsa-miR Name-Assay#

FC (NEVUS30/MEL30)

Log2(FC)

p value

FDR (BH)

FC Bin

hsa-miR-650-4381006

0.1393

-2.8436

0.0000

0.0036

FC > 4

hsa-let-7iSTAR-4395283

4.3578

2.1236

0.0111

0.2768

FC > 4

hsa-miR-572-4381017

0.3278

-1.6091

0.0117

0.2768

FC 2.0-4.0

hsa-miR-135aSTAR-4395343

0.4993

-1.0021

0.0175

0.2768

FC 2.0-4.0

hsa-miR-768-3p-4395188

1.5165

0.6008

0.0181

0.2768

FC 1.2-1.6

hsa-miR-604-4380973

0.3778

-1.4043

0.0188

0.2768

FC 2.0-4.0

hsa-miR-223STAR-4395209

0.1451

-2.7853

0.0200

0.2768

FC > 4

hsa-miR-639-4380987

0.5274

-0.9230

0.0284

0.3442

FC 1.6-2.0

hsa-miR-214STAR-4395404

0.6008

-0.7349

0.0438

0.4602

FC 1.6-2.0

hsa-miR-409-3p-4395443

0.5134

-0.9619

0.0474

0.4602

FC 1.6-2.0

  1. Array A: TLDA panel A (377 functionally defined microRNAs) array B: TLDA panel B (290 MicroRNAs whose function is not yet completely defined) TLDA A and B totaled 667 microRNA assays. FC: fold change; Pvalue student T test ≤ 0.05; FDR: false discovery rate; FC bin: Range of fold change. MirRs in bold font were found to be significantly differentially expressed between the two groups by the relative quantification (ABqPCR software-Analysis I) based method and by Class Comparison (BRB tools-Analysis II) based on absolute CT values normalized to endogenous control MammU6 (see materials and methods). N/A: not applicable.
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Journal of Translational Medicine

ISSN: 1479-5876

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