Morphologic complexity of epithelial architecture for predicting invasive breast cancer survival

Table 2 Univariate Results from Kaplan-Meier Analysis and Cox Proportional Hazards Regression

	Number of Patients	10-year Disease- Specific Survival (%)	Univariate Hazard Ratio (95% CI)	P-value	10-year Overall Survival (%)	Univariate Hazard Ratio (95% CI)	P-value
Fractal dimension
< 1.56	141	69.4	1.0		67.4	1.0
1.56 - 1.75	148	56.4	1.9 (1.1, 3.6)	0.03	39.9	2.1 (1.2, 3.6)	0.008
>1.75	90	25.0	3.5 (1.9, 6.4)	< 0.001	14.2	3.6 (2.1, 6.1)	< 0.001
Age
≤ 55 years	78	82.1	1.0		82.1	1.0
>55 years	301	40.8	3.3 (1.5, 7.2)	0.003	29.1	4.3 (2.0, 9.4)	< 0.001
Size of tumour
≤ 2 cm	272	49.2	1.0		38.8	1.0
>2 cm	107	57.0	1.3 (0.8, 2.2)	0.21	47.9	1.3 (0.9, 2.0)	0.18
Grade of tumour
1 & 2	338	56.1	1.0		45.4	1.0
3	41	22.1	3.4 (2.0, 5.7)	< 0.001	19.3	2.8 (1.7, 4.6)	< 0.001
Lymph node status
Negative	300	57.6	1.0		47.8	1.0
Positive	79	32.2	4.0 (2.5, 6.3)	< 0.001	21.3	3.4 (2.3, 5.1)	< 0.001
Estrogen-receptor status
Positive	355	53.8	1.0		43.1	1.0
Negative	24	40.1	1.6 (0.7, 3.4)	0.26	36.0	1.6 (0.8, 3.1)	0.19
HER-2/neu status
Negative	350	51.6	1.0		42.3	1.0
Positive	29	60.6	1.2 (0.5, 2.7)	0.71	38.9	1.2 (0.6, 2.5)	0.59

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