Sunitinib treatment improved survival in nude mice bearing Tsc2-/- tumors. (a) Average tumor volume over time for sunitinib and sunitinib plus rapamycin treated animals. (b) Survival curve for indicated treatment cohorts. Based on survival analysis and comparison of tumor volumes on day 30, sunitinib improves survival but does not decrease tumor growth compared to the untreated cohort. Sunitinib is not as effective as single agent rapamycin in improving survival or decreasing tumor growth. Based on analysis and comparisons of tumor volumes on day 65, sunitinib in combination with rapamycin provided no improvement over single agent rapamycin treatment.