Figure 4
Long-term frequency changes for the T CM consensus phenotype, CCR7+CD45RA-CD57-CD27+CD28+ ( +--++ ) and two associated supersets. (A) Plot illustrating the statistically significant increase in the TCM consensus phenotype frequency between PIVR and LTM for all 7 patients. (B) The concomitant decrease between LTM and P2B for the frequency of the consensus TCM phenotype. (C) The longitudinal expression profile for the TCM consensus phenotype showing LTM peaks for 4 of 7 patients; longitudinal profile for the CD45RA unspecified superset, CCR7+CD57-CD27+CD28+ (+.-++), showing LTM peaks for 6 of 7 patients; and longitudinal profile for the CD45RA, CD27, and CD28 unspecified superset, CCR7+CD57- (+.-..), also showing LTM peaks for 6 of 7 patients. Data suggests CD45RA, CD27, and CD28 may not be obligate descriptors for central memory T cells.