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Table 1 A summary of existing animal models of brain tumors

From: Immunological considerations of modern animal models of malignant primary brain tumors

  Tumorigenesis Method Technique Tumor Animal Ref
Implantation 9 L Gliosarcoma Syngeneic Graft GS Rat [17]
  C6 Syngeneic Graft GBM Rat [2]
  T9 Syngeneic Graft GS Rat [4]
  RG2 Syngeneic Graft GBM Rat [4]
  F98 Syngeneic Graft GBM Rat [4]
  RT-2 Syngeneic Graft GBM Rat [4]
  CNS-1 Syngeneic Graft GBM Rat [18]
  GL261 Syngeneic Graft GBM Mouse [23]
  Human Tumor Cells (U87, U251) Xenograft GBM Mouse [5]
Genetic p53 +/-, NF-1 +/- Germline mutations Astro Mouse [24]
  GFAP- p53 +/-, NF-1 +/- Conditional KO Astro Mouse [78]
  GFAP- p53 +/-, NF-1 +/-, PTEN-/- Conditional KO Astro Mouse [78]
  GFAP- p53 +/-, PTEN-/- Conditional KO Astro Mouse [87]
  INK4a/ARF -/-, PDGF Overexpression Germline mutation, RCAS Astro Mouse [47]
  INK4a/ARF -/-, EGF-R overexpression Germline mutation, RCAS Astro Mouse [48]
  INK4a/ARF -/-, Ras, Akt overexpression Germline mutation, RCAS Astro Mouse [49]
  Ras, Akt overexpression RCAS Astro Mouse [80]
  Ras, Akt overexpression, PTEN -/- RCAS, Conditional KO Astro Mouse [80]
  GFAP-V12 Ras, EGFRvIII Astrocyte targeted mutation, Adenovirus Astro Mouse [77]
  GFAP-V12 Ras, PTEN -/- Astrocyte targeted mutation, Germline mutation Astro Mouse [56]
  RAS, EGF-R targeted overexpression Astrocyte targeted mutations Astro Mouse [73]
  PDGF-B overexpression MMLV retrovirus ODG Mouse [75]
  PDGF-B overexpression RCAS ODG Mouse [76]
  Rb inactivation, PTEN -/- GFAP-Cre targeted conditional KO ODG   [82]
  INK4a/ARF -/-, PDGF overexp., PTEN -/- Germline mutation, RCAS, Conditional KO ODG Mouse [88]
  P53 +/-, S100β promoter driven-v-erbB Germline mutation, Oligodendrocyte mutation ODG Mouse [26]
  INK4a-ARF +/-, S100β promoter v-erbB Germline mutation, Oligodendrocyte mutation ODG Mouse [26]
  p53 +/-, EGF-R overexpression Germline mutation, Oligodendrocyte mutation ODG Mouse [48]
  Ptc +/- Germline mutation or Conditional KO MB Mouse [25]
  Ptc +/-, p53 -/- Germline mutations MB Mouse [25]
  Shh, n-Myc RCAS MB Mouse [89]
  Rb +/-, p53 +/- GFAP-conditional KO MB Mouse [84]
  BRCA2 -/-, p53 +/- Nestin-conditional KO MB Mouse [86]
  Xrcc4 -/-, p53 -/- Nestin-conditional KO MB Mouse [81]
  SmoM2 GFAP-conditional KO MB Mouse [79]
  1. (abbreviations (GS-Gliosarcoma, GBM-glioblastoma multiforme, Astro-astrocytoma, ODG-oligodendroglioma, MB-Medulloblastoma, KO-knockout)