Table 1 A summary of existing animal models of brain tumors

Implantation

9 L Gliosarcoma

Syngeneic Graft

C6

Syngeneic Graft

T9

Syngeneic Graft

RG2

Syngeneic Graft

F98

Syngeneic Graft

RT-2

Syngeneic Graft

CNS-1

Syngeneic Graft

GL261

Syngeneic Graft

Human Tumor Cells (U87, U251)

Xenograft

Genetic

p53 +/-, NF-1 +/-

Germline mutations

GFAP- p53 +/-, NF-1 +/-

Conditional KO

GFAP- p53 +/-, NF-1 +/-, PTEN-/-

Conditional KO

GFAP- p53 +/-, PTEN-/-

Conditional KO

INK4a/ARF -/-, PDGF Overexpression

Germline mutation, RCAS

INK4a/ARF -/-, EGF-R overexpression

Germline mutation, RCAS

INK4a/ARF -/-, Ras, Akt overexpression

Germline mutation, RCAS

Ras, Akt overexpression

RCAS

Ras, Akt overexpression, PTEN -/-

RCAS, Conditional KO

GFAP-V¹² Ras, EGFRvIII

Astrocyte targeted mutation, Adenovirus

GFAP-V¹² Ras, PTEN -/-

Astrocyte targeted mutation, Germline mutation

RAS, EGF-R targeted overexpression

Astrocyte targeted mutations

PDGF-B overexpression

MMLV retrovirus

PDGF-B overexpression

RCAS

Rb inactivation, PTEN -/-

GFAP-Cre targeted conditional KO

INK4a/ARF -/-, PDGF overexp., PTEN -/-

Germline mutation, RCAS, Conditional KO

P53 +/-, S100β promoter driven-v-erbB

Germline mutation, Oligodendrocyte mutation

INK4a-ARF +/-, S100β promoter v-erbB

Germline mutation, Oligodendrocyte mutation

p53 +/-, EGF-R overexpression

Germline mutation, Oligodendrocyte mutation

Ptc +/-

Germline mutation or Conditional KO

Ptc +/-, p53 -/-

Germline mutations

Shh, n-Myc

RCAS

Rb +/-, p53 +/-

GFAP-conditional KO

BRCA2 -/-, p53 +/-

Nestin-conditional KO

Xrcc4 -/-, p53 -/-

Nestin-conditional KO

SmoM2

GFAP-conditional KO