Table 1 HIV-Modulated Proteins Associated With Essential Steps During Angiogenesis
Protein names and Abbreviations | Accession # | P-Value related to Angiogenesis |
|---|---|---|
1. Activation of T-Cells: Transcriptional and Translational Reprogramming | ||
T-cell receptor zeta chain, tyrosine-protein kinase (ZAP-70) | P43403 | 4 × 10-5 |
TNF receptor (TNR) superfamily # 9 (TNR9) | Q07011 | 8 × 10-8 |
Complement receptor 3 (CO3/C3)* | P01024 | 1 × 10-6 |
Beta type serine/threonine protein kinase C (PKC)* | P05771 | 8 × 10-12 |
2. Regulation of Cell Cycle: Lipid Kinase, Endothelial zinc finger and p53-binding protein | ||
Phosphatidylinositol-4-phosphate3-kinase C2-beta (P3C2B/PI3K) | O00750 | 8 × 10-12 |
Endothelial zinc finger protein (ZNF71) | Q9NQZ8 | N/A |
Tumor suppressor p53-binding protein 1 (TP53B) | Q12888 | 2 × 10-8 |
3. Augmentation of Cell Growth: Overexpression of Receptor Protein Tyrosine Kinases | ||
ERBB2 receptor protein tyrosine kinase (ERB2) | P04626 | 2 × 10-10 |
Growth factor receptor-bound protein 2 (GRB2) | P62993 | 8 × 10-12 |
Vascular endothelial cell growth factor C (VEGFC) Not expressed | P49767 | 2 × 10-10 |
VEGF receptor tyrosine kinase VEGFR-2 (VGFR2) Not expressed | P35968 | 8 × 10-12 |
4. Survival of Newly Formed Cells: Serine-Threonine Protein Kinase C (PKC) and Adapter Proteins | ||
Beta type serine/threonine protein kinase C (PKC)* | P05771 | 8 × 10-12 |
Protein kinase C-binding protein NELL1 (NELL1) | Q92832 | 8 × 10-8 |
Annexin VI (ANXA6) | P08133 | 3 × 10-4 |
14-3-3 protein gamma (143G) | P61981 | 3 × 10-10 |
5. Mitogenic Signaling Cascade; Mitogen-activated Protein Kinase | ||
Mitogen-activated protein kinase (MAPK3) | P27361 | 8 × 10-12 |
CRK-like adapter protein (CRKL) | P46109 | 5 × 10-10 |
6. Balanced Cell Growth or Adhesion: Anti-angiogenic G-Protein Coupled Receptors | ||
Brain-specific angiogenesis inhibitor 1 (BAI1) | O14514 | 2 × 10-10 |
Brain-specific angiogenesis inhibitor 3 (BAI3) | O60242 | N/A |
7. Adhesion, Differentiation & Cell Migration: Focal Adhesion Kinase, Adhesion Receptor & Enzymes | ||
Focal adhesion tryosine kinase 2 beta (FAK2) | Q14289 | 2 × 10-9 |
Alpha (V) beta (5) integrin (ITB5) | P18084 | 2 × 10-9 |
Nitric-oxide synthase (NS2A) | P35228 | 2 × 10-9 |
Fibronectin Precursor (FINC) | P02751 | 1.5 × 10-3 |
Low molecular weight phosphotyrosine protein phosphatase (PPAC) | P24666 | 2 × 10-9 |
8. Morphogenesis and Cell Migration: Laminins and other Cell Adhesion Molecules | ||
Laminin beta-2 chain precursor (LAMB2)Upregulated | P55268 | 2 × 10-8 |
Laminin alpha-5 chain protein precursor (LAMA5) | O15230 | 2 × 10-10 |
Cadherin EGF LAG seven-pass G-type receptor 1 (CLR1/CELSR1) | Q9NYQ6 | N/A |
Protocadherin focal adhesion targeting (FAT2) | Q9NYQ8 | 7 × 10-6 |
Golgi apparatus Protein 1 (GLG1) | Q92896 | N/A |
9. Cell Permeability & Sprouting: Myosin Light Chain Kinase, Aggrecans & Peptidase | ||
Myosin light chain kinase smooth muscle/non-muscle isoezymes (KMLS) | Q15746 | 3 × 10-12 |
ADAMTS-9 (ATS9) | Q9P2N4 | 4 × 10-4 |
Complement receptor 3 (CO3/C3)* | P01024 | 1 × 10-6 |
10. Preservation of Differentiated Cellular Phenotype: Coagulation-related Factor | ||
Von Wilebrand factor (VWF) | P04275 | 2 × 10-7 |