Figure 5

Analysis of the impact of ApoG2 in vivo on c-Myc expression and tumor growth in CNE-2 xenografts. The tumor tissues from ApoG2 (120 mg/kg intraperitoneal injection daily) treatment were obtained at the end of 12 days of treatment. Immunochemistry analysis of c-Myc expression in CNE-2 xenograft tumor sections after NS treatment (A) or ApoG2 treatment (B), magnification, × 80. (C) Photographs of CNE-2 xenografts from NS treatment and ApoG2 treatment groups. When all tumors of the control group exceeded 1 g in weight, the animal experiment was terminated and mice were killed. The tumors were taken out for weighing and comparing the effect of ApoG2 on tumors. (D) Antitumor acitivity of ApoG2 in CNE-2 xenograft-bearing nude mice. Compared to control (NS treatment) mice, ApoG2 treatment greatly suppressed tumor weight. Bar heights, average weight of eight CNE-2 xenograft tumors; bars, SD.