Table 2 MPA exposure and IMPDH activity

C₀ (mg/L)

1

3.1

(2.7–3.8)

1.4

(0.7–2.3)

2.7

(0.7–3.8)

2

1.9

(1.7–5.5)

1.9

(0.8–2.3)

1.9

(0.8–5.5)

13

3.2

(2.9–7.6)

2.9

(2.4–3.0)

3.0

(2.4–7.6)

AUC_{0–9 h}

(mg × h/L)

1

44.4

(28.2–70.8)

37.1

(17.9–40.1)

40.1

(17.9–70.8)

2

35.1

(33.6–47.6)

26.4

(16.3–37.8)

34.4

(16.3–47.6)

13

48.5

(39.1–64.1)

37.4

(27.2–59.0)

43.8

(27.2–64.1)

C_max (mg/L)

1

12.8

(7.7–15.4)

11.0

(5.2–19.5)

11.3

(5.2–19.5)

2

12.1

(9.7–15.1)

7.8

(4.4–10.9)

10.9

(4.4–15.1)

13

17.9

(8.1–21.4)

11.3

(5.3–13.7)

12.5

(5.3–21.4)

IMPDH activity in CD4+ cells

A₀

(pmol/10⁶ cells/min)

0

0.24

(0.16–0.31)

0.61

(0.3–0.95)

0.31

(0.16–0.95)

1

0.96

(0.70–1.4)

0.63

(0.37–1.53)

0.92

(0.37–1.53)

2

0.43

(0.25–0.71)

1.1

(0.66–1.53)

0.60

(0.25–1.53)

13

0.70

(0.32–2.7)

0.28

(0.2–1.87)

0.51

(0.2–2.72)

AUC_{0–9 h}

(% of A₀ × h)

1

760

(472–908)

1197

(904–1491)

884

(472–1491)

2

1168

(694–3142)

760

(488–1032)

1032

(488–3142)

13

3034

(414–3784)

3044

(765–3111)

3039

(414–3784)

A_min

(% of A₀)

1

45.5

(25.4–58.1)

46.1

(39.0–100)

46.1

(25.4–100)

2

77.4

(48.0–100)

64.3

(32.6–96.0)

77.4

(32.6–100)

13

100

(7.6–100)

100

(13.0–100)

100

(7.6–100)

A_max

(% of A₀)

1

141

(103–184)

170

(100–254)

160

(100–254)

2

255

(113–524)

119

(100–137)

184

(100–524)

13

627

(106–707)

523

(148–525)

524

(106–707)