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Table 2 Comparison of discriminating spectral components/peptide peaks found in this study and in other published work.

From: Mass spectrometry-based serum proteome pattern analysis in molecular diagnostics of early stage breast cancer

This study

Other studies

m/z value

p-value

Change

m/z value

p-value

Change

Ref.

Study design

Identity

2303.48

6.25e-14

D

2306.20

1.09e-06

U

35

MALDI/serum/A

C4a

2356.91

2.47e-04

D

2359.09

4.07e-12

U

35

MALDI/serum/A

ITIH4

2378.80

8.91e-06

D

2380.03

1.26e-07

U

35

MALDI/serum/A

Fibrinogen

2510.80

4.65e-08

D

2509.16

5.56e-13

U

35

MALDI/serum/A

ApoA-IV

2599.75

6.03e-04

U

2603.15

2.08e-07

U

35

MALDI/serum/A

Factor XIIIa

3020.51

5.49e-03

U

3017.85

1.50e-03

U

43

SELDI/NAF/M

 

3273.96

1.08e-03

U

3278.71

1.05e-05

D

42

SELDI/serum/M

 

3283.73

6.80e-07

U

3281.5

1.77e-04

U

38

MALDI/serum/M

 

3973.35

1.51e-06

D

3284.74

3.00e-04

U

43

SELDI/NAF/M

 

4648.09

3.48e-07

U

3975.99

3.06e-05

D

42

SELDI/serum/M

 

5105.44

4.66e-03

U

4648

4.13e-03

D

42

SELDI/serum/M

 

6802.40

1.42e-03

D

5101.8

4.90e-03

U

43

SELDI/NAF/M

 

8116.60

3.41e-04

D

6807.26

1.90e-03

D

42

SELDI/serum/M

 

8134.75

9.61e-04

D

8116

1.00e-06

U

29,33

SELDI/serum/M

C3a

8656.46

2.73e-04

U

8138.56

7.89e-07

U

42

SELDI/serum/M

 
   

8657.2

1.00e-03

U

37

SELDI/Serum/E

 
  1. Uncorrected p-values are based on Mann-Whitney U tests in this study. Correspondence of peptide peaks is based on a difference of less than ± 0.2% of the m/z values of [M+H]+ ions. The column "Change" refers to an increased (U) or decreased (D) abundance of a given peptide in breast cancer samples comparing to control samples, and the column "Identity" shows the protein from which the corresponding fragment is derived. Corresponding peptide peaks were found in six studies based on either MALDI or SELDI spectrometry; patient groups consisted of either early (E), advanced (A) or mixed (M) stages. One study analyzed the nipple aspirate fluid (NAF).
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Journal of Translational Medicine

ISSN: 1479-5876

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