Figure 2

Pharmacokinetics of Gd-dendrimer generations in orthotopic RG-2 gliomas and ectopic RG-2 gliomas over 600 to 700 minutes. Respective Gd-dendrimer generation was intravenously infused over 1 minute (0.09 mmol Gd/kg) during the initial 15 minute dynamic contrast-enhanced MRI scan session. Subsequent dynamic scan sessions of re-anesthetized animals were conducted at 30 to 90 minute time intervals. Whole tumor tissue Gd concentrations for the orthotopic and ectopic RG-2 gliomas were calculated for each of the dynamic scan session time points. Shown is the change in the Gd concentration of respective Gd-dendrimer generations in orthotopic RG-2 gliomas and ectopic RG-2 gliomas over 600 to 700 minutes. Superimposed is the best fit curve Gd concentration curve for the respective Gd-dendrimer generations. Panels A through D are orthotopic glioma Gd concentrations over time. Panels E through H are ectopic glioma Gd concentrations over time A. Gd-G5 (Orthotopic, N = 6), B. Gd-G6 (Orthotopic, N = 6), C. Gd-G7 (Orthotopic, N = 5), D. Gd-G8 (Orthotopic, N = 5), E. Gd-G5 (Ectopic, N = 6), F. Gd-G6 (Ectopic, N = 6), G. Gd-G7 (Ectopic, N = 5), H. Gd-G8 (Ectopic, N = 5).