Progesterone receptor does not improve the performance and test effectiveness of the conventional 3-marker panel, consisting of estrogen receptor, vimentin and carcinoembryonic antigen in distinguishing between primary endocervical and endometrial adenocarcinomas in a tissue microarray extension study

Table 5 Comparisons of the test effectiveness and performance between the 3-marker and 4-marker panels with typical EC type, typical EM type, typical EC type + PR (-) and typical EM type + PR (+) expressions in 14 ECA and 24 EMA

	ECA		EMA
Panel compositions	3-marker Typical EC type	4-marker Typical EC type + PR(-)	3-marker Typical EM type	4-marker Typical EM type + PR(+)
Sensitivity (95% CI)	0.571 (0.414, 0.729)	0.571 (0.414, 0.729)	0.458 (0.296, 0.621)	0.375 (0.217, 0.533)
Specificity (95% CI)	0.958 (0.895, 1.000)	0.958 (0.895, 1.000)	1.000 (1.000, 1.000)	1.000 (1.000, 1.000)
Positive predictive value (95% CI)	0.889 (0.789, 0.989)	0.889 (0.789, 0.989)	1.000 (1.000, 1.000)	1.000 (1.000, 1.000)
Negative predictive value (95% CI)	0.793 (0.664, 0.922)	0.793 (0.664, 0.922)	0.519 (0.355, 0.682)	0.483 (0.320, 0.646)
Accuracy (95% CI)	0.80 (0.667, 0.933)	0.80 (0.667, 0.933)	0.686 (0.534, 0.837)	0.657 (0.502, 0.812)

1. -: negative score, +: positive score, 95% CI: 95% confidence interval.
2. Typical EC-type: immunoprofile expression with ER-/Vim-/CEA+
3. Typical EM-type: immunoprofile expression with ER+/Vim+/CEA-
4. PR (-) attributable to typical EC-type panel and PR (+) attributable to typical EM type panel.

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