Vitamin D status in critically ill subjects with sepsis, critically ill subjects without sepsis and healthy subjects. Plasma 25-hydroxyvitamin D levels in critically ill subjects with sepsis (hatched bar) and in critically ill control subjects without sepsis (dark bar) were significantly lower than healthy controls (white bar) (ANOVA, p < 0.0001). 25-hydroxyvitamin D concentrations were adjusted for race. ‡ p < 0.001, critically ill sepsis subjects compared to healthy controls. # p < 0.01, critically ill control subjects compared to healthy controls.