Figure 5

The sigma-2 ligand, SV119, combined with gemcitabine suppresses tumor growth and increases survival in model pancreatic adenocarcinoma in vivo. C57BL/6 mice bearing established tumor allografts were treated with every other day SV119 (1 mg/mouse, i.p. for 7 days) and weekly gemcitabine (3 mg/mouse, i.p. for two weeks). Mean tumor diameter (Panel A) and survival (Panel B) were measured. * = vs. control.