Figure 3
Probability of One or More Positive Test Results by Specimens Tested, Under Varying Assumptions Regarding Proportion of True Positive Specimens. Curves are constructed based on a binomial distribution. Each contour represents a different proportion of true positive test specimens. Graph (A) represents estimates generated based on high (100%) sensitivity estimated for real-time reverse-transcriptase polymerase chain reaction using both latent class modeling (LCM) and composite reference standard (CRS) methods. Graph (B) presents estimates generated using LCM estimates for enzyme immunoassay (EIA) sensitivity (86%). A graph using EIA sensitivity estimates from CRS would be similar to graph (A) due to high (97%) sensitivity estimates using the latter approach.