Figure 3

Public motifs in Melan-A-specific clonotypes. Aminoacidic composition and sequence alignments of public CDR3 of Melan-A-specific clonotypes found in melanoma patients. ^aPBL: peripheral blood lymphocytes; ^bTIL: tumor infiltrating lymphocytes; ^cNA: ID not available; ^dm: modified Melan-A A27L; ^eClonotype 4 was obtained from one T- clone was obtained before and one after vaccination; ^fX: amino acid not available; ^gn: natural Melan-A. In dark gray: amino acids identical to the consensus sequences; in light gray: other preferentially used amino acids at the given position; in bold: amino acids belonging to N-D-N region; in the boxes: hydrophilic amino acids at position 109 and 114.