Figure 1

TRB segments usage. TRBV (A) and TRBJ (B) segments usage and CDR3 length (C) in clonotypes prepared from Melan-A-specific CTL lines and/or clones of melanoma patients (Mel/M-A), clonotypes from Melan-A-specific CTL of healthy controls and of a patient with vitiligo (Ctrl/M-A), clonotypes of melanoma patients specific for melanoma Ags other than Melan-A or with unknown specificity (Mel/noM-A), clonotypes from HLA-A2+ subjects derived from T lymphocytes specific for Ags unrelated to melanoma (Ctrl/HLA-A2+). The sequences analyzed here are those reported in Table 1. As indicated in Table 1, in some papers a pre-selection of cells bearing some specific TRBV segments was done before sequencing. * TRBV and TRBJ chains preferentially used within clonotype groups. The TRB nomenclature used throughout the paper is that of Lefranc et al [1]; the nomenclature reported in parenthesis is that of Arden et al [49]. (aa): amino acids.