| Â | Â | Orthotopic mouse model |
|---|
| Â | Â | Control at 10 days | CHS 828 at 10 days | CHS 828 at 30 days |
|---|
INSS | stage 1 | 0% (0/9) | 46% (6/13) | 60% (6/10) |
| Â | stage 2a | 0% (0/9) | 8% (1/13) | 0% (0/10) |
| Â | stage 3 | 0% (0/9) | 0% (0/13) | 0% (0/10) |
| Â | stage 4b | 100% (9/9) | 46% (6/13) | 40% (4/10) |
- Postmortem classification of control and CHS 828-treated animals using the INSS criteria for staging [27].
- aNo extensive lymph node investigation was performed; therefore, "stage 2" was not divided into "2A" and "2B"
- bINSS stage 4 was not separated into stages 4 and 4S since 4S is for infants
- INSS (International Neuroblastoma Staging System) according to Simpson and Gaze [27] at autopsy
