Figure 2
Orthotopic NB growth in SCID mice. SCID mice carrying orthotopic NB xenotransplants were randomized at an estimated tumor volume of 0.8 ml (â–¡ n = 10, controls; â– n = 23, for CHS 828 treatment). After randomization, mice were treated daily with either vehicle (â–¡ n = 9; 10 days) or with CHS 828 (20 mg/kg; p.o.) for 10 (â– n = 13) or 30 (â– n = 10) days. Mann-Whitney U test was used to evaluate differences between the groups.