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Table 1 MECHANISMS OF HIV-PROTECTION BY ANTI-CD4 ANTIBODIES

From: Protective versus pathogenic anti-CD4 immunity: insights from the study of natural resistance to HIV infection

1) interference with gp120 binding
Antibody Binding site Binding to CD4-gp120 complex Characteristics
OKT4a[76] First CD4 domain Does not occur due to epitope masking Difficult to generate in vivo
Immune suppressive
2) interference with the sequence of conformational modifications subsequent to gp120 binding and permissive to coreceptor binding and membrane fusion
Antibody Binding site Binding to CD4-gp120 complex Characteristics
Ibalizumab[46] Second CD4 domain Equivalent binding to free and complexed CD4 Non immune suppressive
DB-81[59, 60] Second CD4 domain Increased binding to complexed CD4 a) Non immune suppressive;
b) Fine specificity shared by ESN individuals