Figure 1
From: Aurora kinase inhibitors synergize with paclitaxel to induce apoptosis in ovarian cancer cells
Aurora-A is overexpressed in carcinomas. Heat map image of Z-score normalized microarray expression data from Affymetrix U95A gene chips. Genes with lower expression compared to normal tissue are shown in blue and yellow indicates genes that are overexpressed. (A) Heat map representing the entire data set. Arrow indicates Aurora-A. (B) Aurora-A is overexpressed 5 fold in carcinomas compared to adenomas. Both Aurora-A probes are shown. Ca – carcinoma, Ad – adenoma, CC – cancers pre-treated with chemotherapy. (C) Ingenuity Pathway Assist analysis of significantly overexpressed genes. Diagram represents an interaction network of the 8 genes and Aurora-A kinase. (D) Low power (2×) image of ovarian tissue microarray stained for Aurora A by immunohistochemistry. (E) Aurora-A staining of TMA core of ovarian carcinoma without adjuvant chemotherapy (20×). (F) Aurora-A staining of TMA core of benign ovarian tissue (20×). (G) Aurora-A staining of TMA core of ovarian carcinoma with adjuvant chemotherapy (20×).