Figure 3

IGFBP-3 and -4 sera concentration for primary and metastatic patients. A. Median IGFBP-3 in sera of primary patients was 3.4 μg/ml compared with 4.9 μg/ml, in metastatic patients (p = 0.08 by Wilcoxon rank-sum test). B. Median IGFBP-4 in sera of primary patients was 37.2 ng/ml compared with 41.2 ng/ml, in metastatic patients (p = 0.25 by Wilcoxon rank-sum test). The boxes represent the inter-quartile distances with upper and lower limits of the boxes indicating the 75^th and 25^th percentiles, respectively, and the central, horizontal line representing the median. Outliers are values that are more than 1.5 times the inter-quartile distance above the 75^th or below the 25^th percentile and are indicated by points outside of the box and whiskers.