Table 6 Genes found by genetic programming for discrimination between SCLC, NSCLC (AC and SCC) and normal lung tissue.
Gene Symbol | Gene Name | Location |
|---|---|---|
Discrimination AC vs. rest | ||
CLCA2 | chloride channel, calcium activated, family member 2 | 1p31-p22 |
EFS | embryonal Fyn-associated substrate | 14q11.2-q12 |
FGG | fibrinogen, gamma polypeptide | 4q28 |
GPCR5A | G protein-coupled receptor, family C, group 5, member A | 12p13-p12.3 |
KRT7 | keratin 7 | 12q12-q13 |
KRT5 | keratin 5 (epidermolysis bullosa simplex) | 12q12-q13 |
PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 7q31.3 |
SEMA3F | sema domain, immunoglobulin domain (Ig), (semaphorin) 3F | 3p21.3 |
SERPINA1 | serine (or cysteine) proteinase inhibitor, clade A member 1 | 14q32.1 |
SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 4q22-q24 |
Discrimination SCC vs. rest | ||
ADCY3 | adenylate cyclase 3 | 2p24-p22 |
ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 12q21.3 |
CASK | calcium/calmodulin-dependent serine protein kinase | Xp11.4 |
CHST2 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 | 3q24| 7q31 |
DGKA | diacylglycerol kinase, alpha 80kDa | 12q13.3 |
GOLPH2 | golgi phosphoprotein 2 | 9q21.33 |
KIF13B | kinesin family member 13B | 8p12 |
RAB17 | RAB17, member RAS oncogene family | 2q37.3 |
RAB40B | RAB40B, member RAS oncogene family | 17q25.3 |
SCNN1A | sodium channel, nonvoltage-gated 1 alpha | 12p13 |
Discrimination SCLC vs. rest | ||
CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | 3p24.1-p21.2 |
CTSH | cathepsin H | 15q24-q25 |
DLK1 | delta-like 1 homolog (Drosophila) | 14q32 |
ERBB2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 | 17q11.2-q12 |
FANCA | Fanconi anemia, complementation group A | 16q24.3 |
ID4 | inhibitor of DNA binding 4, dominant helix-loop-helix protein | 6p22-p21 |
ISL1 | ISL1 transcription factor, LIM/homeodomain, (islet-1) | 5q11.2 |
MGC13024 | hypothetical protein MGC13024 | 16p11.2 |
POU4F1 | POU domain, class 4, transcription factor 1 | 13q21.1-q22 |
XYLT2 | xylosyltransferase II | 17q21.3-17q22 |
Discrimination NT vs. rest | ||
ALOX15 | arachidonate 15-lipoxygenase | 17p13.3 |
ANKMY1 | ankyrin repeat and MYND domain containing 1 | 2q37.3 |
C18orf43 | chromosome 18 open reading frame 43 | 18p11.21 |
DNAI1 | dynein, axonemal, intermediate polypeptide 1 | 9p21-p13 |
GSTA3 | glutathione S-transferase A3 | 6p12.1 |
LRRC6 | leucine rich repeat containing 6 | 8q24.22 |
MIPEP | mitochondrial intermediate peptidase | 13q12 |
NKX3-1 | NK3 transcription factor related, locus 1 (Drosophila) | 8p21 |
RTDR1 | rhabdoid tumor deletion region gene 1 | 22q11.2 |
VNN3 | vanin 3 | 6q23-q24 |