Table 4 Selection of significantly differentially expressed genes in small cell lung cancer focusing on proliferation, oncogenesis and cell adhesion.
Gene Symbol | Gene Name | Fold Change SCLC vs. NT | q-value |
|---|---|---|---|
proliferation | |||
RFC4 | replication factor C (activator 4) | 5.56 | 0.09 |
p16/CDKN2A | cyclin-dependent kinase inhibitor 2A | 5.15 | 0.23 |
CENPA | centromere protein A | 4.68 | 0.09 |
CCNE | Cyclin E | 4.48 | 0.09 |
CCNB2 | Cyclin B2 | 4.43 | 0.09 |
PRC1 | protein regulator of cytokinesis 1 | 4.23 | 0.28 |
CENPF | centromere protein F | 4.01 | 0.23 |
MAD2L1 | mitotic arrest deficient-like 1 | 3.78 | 0.09 |
HEC1 | kinetochore associated 2 | 3.66 | 0.09 |
PIR51 | RAD51 associated protein1 | 3.60 | 0.09 |
BUB1B | budding uninhibited by benzimidazoles 1 homolog beta | 3.51 | 0.09 |
CDC2 | cell division cycle 2 | 3.42 | 0.28 |
PCNA | proliferating cell nuclear antigen | 3.12 | 0.09 |
RFC3 | replication factor C (activator 3) | 2.58 | 0.09 |
RFC5 | replication factor C (activator 5) | 2.55 | 0.09 |
CDK4 | cyclin-dependent kinase 4 | 2.55 | 0.09 |
NEK2 | never in mitosis gene a-related kinase 2 | 2.48 | 0.09 |
CDK2 | cyclin-dependent kinase 2 | 2.41 | 0.09 |
BUB1 | budding uninhibited by benzimidazoles 1 homolog | 2.38 | 0.09 |
CENPE | centromere protein E | 2.38 | 0.09 |
ENC1 | ectodermal-neural cortex 1 | 2.32 | 0.23 |
MSH2 | mutS homolog 2 | 2.31 | 0.09 |
FANCG | Fanconi anemia, complementation G | 2.22 | 0.09 |
MSH6 | mutS homolog 6 | 2.09 | 0.09 |
CCNA2 | Cyclin A2 | 2.07 | 0.09 |
oncogenesis | |||
FOXG1B | Forkhead BOX G1B, QIN oncogene | 16.76 | 0.09 |
STMN1 | stathmin 1/oncoprotein 18 | 4.98 | 0.16 |
FYN | fyn oncogene related to src, fgr, yes | 3.91 | 0.16 |
MAGED4 | melanoma antigen, family D, 4 | 3.51 | 0.28 |
PTTG1 | pituitary tumor-transforming 1 | 2.56 | 0.09 |
RACGAP1 | Rac GTPase activating protein 1 | 3.30 | 0.09 |
DEK | DEK oncogene (DNA binding) | 2.49 | 0.16 |
RAN | Ras-Related Nuclear Protein | 2.39 | 0.16 |
RANBP1 | RAN binding protein 1 | 2.39 | 0.16 |
TPD52 | tumor protein D52 | 2.08 | 0.16 |
RABL2B | Rab-like 2B | 0.44 | 0.09 |
RABL2 | Rab-like 2A | 0.40 | 0.09 |
Cell adhesion | |||
NCAM1 | neural cell adhesion molecule 1 | 12.75 | 0.16 |
NRCAM | neuronal cell adhesion molecule | 9.43 | 0.09 |
CDH2 | N-cadherin | 5.41 | 0.09 |
CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | 2.46 | 0.09 |
TJP3 | tight junction protein 3, zona occludens 3 | 0.45 | 0.09 |