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Table 4 Genes differentially expressed (1.5-fold) at ≥ 6 time points

From: Cyclic changes in gene expression induced by Peg-interferon alfa-2b plus ribavirin in peripheral blood monocytes (PBMC) of hepatitis C patients during the first 10 weeks of treatment

Symbol Day 3 Day 6 Day 10 Day 13 Day 27 Day 42 Day 70 Description
Up regulated         
Gene name         Other name/function
AGRN 2.1 1.7 2.1 1.9 1.6 1.7 2.1 agrin
APOBEC3A 2.9 2.0 2.7 1.9 1.9 1.8 2.0 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
CHMP5 2.8 1.9 2.6 2.0 1.9 1.8 1.9 chromatin modifying protein 5
DDX58 2.8 1.8 2.6 1.7 1.8 1.6 1.7 RNA helicase RIG-I
EIF2AK2 2.6 1.9 2.6 2.2 2.0 2.0 2.4 Eukaryotic translation initiation factor 2-alpha kinase 2
FLJ11286 1.8 1.5 1.8 1.6 1.5 1.6 1.6 C19orf66
FLJ20035 3.8 3.0 3.6 2.7 2.5 2.6 2.7 DDX60
H1F0 3.1 1.6 2.1 1.8 1.9 2.1 2.5 H1 histone family, member 0
HERC5 4.5 2.1 4.1 2.5 2.6 2.5 2.7 Ubiquitin ligase/mediates ISGylation of protein targets
HERC6 5.9 4.1 5.7 4.1 4.1 4.2 4.2 Ubiquitin ligase
HIST1H1C 2.6 1.6 2.4 1.7 2.6 2.4 3.2 histone cluster 1, H1c
HIST1H2AE 2.4 2.0 3.3 2.1 2.5 2.6 3.8 histone cluster 1, H2ae
HIST1H2BC 2.5 2.0 2.7 1.9 2.0 2.2 2.8 histone cluster 1, H2bg///histone cluster 1, H2bc
HIST1H2BD 2.1 1.7 2.3 1.6 1.7 1.6 2.2 histone cluster 1, H2bd
HIST1H2BF 2.4 1.9 2.5 1.8 1.9 1.5 2.2 histone cluster 1, H2bf
HIST1H2BG 4.3 2.8 3.6 3.5 3.3 2.4 3.4 histone cluster 1, H2bg
HIST1H2BI 2.4 1.9 2.5 1.9 2.0 1.5 2.2 histone cluster 1, H2bi
HIST2H2AA3 3.1 1.8 2.8 1.8 2.1 2.1 2.8 histone cluster 2, H2aa3///histone cluster 2, H2aa4
IFI27 73.3 70.3 98.0 93.5 94.8 97.4 107.7 interferon, alpha-inducible protein 27 (ISG12, P27)
IFI35 3.2 2.0 2.9 2.0 1.8 1.9 1.9 interferon-induced protein 35
IFI44 7.1 4.8 6.5 4.8 4.5 5.2 5.0 Interferon-induced protein 44, p44
IFI44L 10.1 8.2 9.7 7.6 7.5 8.0 8.4 interferon-induced protein 44-like
IFIH1 3.3 2.0 3.3 2.4 2.1 2.3 2.2 interferon induced with helicase C domain 1
IFIT1 12.2 4.1 9.9 6.0 4.8 5.6 4.8 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 7.1 3.3 6.8 3.8 3.4 3.5 3.9 interferon-induced protein with tetratricopeptide repeats 3
IFIT5 2.7 1.9 2.7 2.4 2.0 2.2 1.8 interferon-induced protein with tetratricopeptide repeats 5
IFITM1 2.0 1.6 1.9 1.7 1.7 1.7 1.7 interferon induced transmembrane protein 1 (9–27)
IFITM3 2.2 1.8 2.1 1.8 1.7 1.8 2.0 interferon induced transmembrane protein 3 (1-8U)
IRF7 3.7 2.4 3.3 2.5 2.2 2.5 2.4 interferon regulatory factor 7
ISG15 6.8 3.8 6.6 4.0 3.9 4.4 4.2 ISG15 ubiquitin-like modifier
ISG20 2.5 1.8 2.6 1.8 1.7 1.6 1.7 interferon stimulated exonuclease gene 20kDa
LAMP3 6.0 3.1 6.7 3.3 3.8 3.9 4.4 lysosomal-associated membrane protein 3
LGALS3BP 4.0 2.2 4.0 2.8 2.6 3.0 3.1 lectin, galactoside-binding, soluble, 3 binding protein
LOC26010 4.3 2.5 4.2 3.0 3.0 3.1 3.3 viral DNA polymerase-transactivated protein 6
LOC391020 2.7 2.0 2.7 2.2 2.1 2.2 2.5 interferon induced transmembrane protein pseudogene
LY6E 4.1 2.7 4.0 3.1 2.8 3.0 3.4 lymphocyte antigen 6 complex, locus E
MX1 5.0 3.5 4.9 3.8 3.7 3.9 4.1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
MX2 3.1 2.1 2.9 2.2 2.2 2.3 2.4 myxovirus (influenza virus) resistance 2 (mouse)
N4BP1 1.5 1.5 1.7 1.6 1.6 1.7 1.6 Nedd4 binding protein 1
OAS1 4.3 2.4 3.8 2.5 2.1 2.3 2.3 2',5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 3.5 2.4 3.4 2.9 2.4 2.5 2.5 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 4.5 2.6 3.8 2.7 2.3 2.5 2.8 2'-5'-oligoadenylate synthetase 3, 100kDa
OASL 4.6 2.1 4.1 2.7 2.2 2.5 2.6 2'-5'-oligoadenylate synthetase-like
PARP12 2.4 1.8 2.3 1.8 1.8 1.9 1.9 poly (ADP-ribose) polymerase family, member 12
PHF11 1.8 1.6 1.8 1.6 1.7 1.7 1.7 PHD finger protein 11
PLSCR1 3.1 1.9 2.8 2.1 2.1 2.1 2.4 phospholipid scramblase 1
RNASE2 2.9 1.9 2.3 1.8 1.7 1.7 1.9 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RSAD2 12.8 5.3 11.6 6.8 6.4 6.4 6.6 radical S-adenosyl methionine domain containing 2
SAMD9 3.8 2.1 3.3 2.6 2.1 2.1 2.0 sterile alpha motif domain containing 9
SERPING1 4.9 1.9 4.1 2.3 1.9 2.0 2.1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)
SIGLEC1 27.1 16.5 23.1 17.0 13.7 18.2 20.9 sialic acid binding Ig-like lectin 1, sialoadhesin
SP100 1.9 1.7 1.9 1.6 1.6 1.5 1.8 SP100 nuclear antigen
SP110 1.9 1.5 1.9 1.5 1.5 1.5 1.6 SP110 nuclear body protein
USP18 7.4 4.9 7.5 5.1 4.5 5.3 5.5 ubiquitin specific peptidase 18
XAF1 4.3 3.3 3.8 2.9 2.9 2.5 3.1 XIAP associated factor-1
ZBP1 3.0 2.2 3.0 2.2 2.1 2.2 2.2 Z-DNA binding protein 1
ZCCHC2 2.3 1.9 2.2 1.7 1.8 1.8 1.8 zinc finger, CCHC domain containing 2
cDNA CSODK002YF13 3.3 2.6 3.4 2.6 2.5 2.7 2.8 Full-length cDNA clone CS0DK002YF13 of HeLa cells Cot 25-normalized of Homo sapiens (human)
cDNA FLJ11754 3.1 2.4 3.1 2.3 2.6 2.6 2.6 CDNA FLJ11754 fis, clone HEMBA1005588
Down regulated         
ALDH1A1 -1.5 -1.7 -1.7 -2.0 -2.5 -2.5 -2.6 aldehyde dehydrogenase 1 family, member A1
CDKN1C 1.9 -2.1 -1.1 -1.7 -1.7 -1.7 -1.7 cyclin-dependent kinase inhibitor 1C (p57, Kip2)
EIF3EIP -2.0 -1.6 -2.0 -1.8 -1.6 -1.6 -1.7 eukaryotic translation initiation factor 3, subunit E interacting protein
EIF4B -2.0 -1.5 -2.0 -1.6 -1.5 -1.9 -1.8 eukaryotic translation initiation factor 4B
FCER1A -1.5 -1.7 -2.1 -2.2 -2.4 -3.0 -2.8 Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
INSR -1.5 -1.6 -1.6 -1.9 -2.0 -2.0 -1.6 insulin receptor
LTA4H -1.7 -1.7 -2.0 -1.7 -1.6 -1.6 -1.6 leukotriene A4 hydrolase
PAPSS2 -1.7 -1.7 -1.8 -1.6 -1.6 -1.3 -1.6 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PID1 -2.0 -1.8 -2.3 -1.8 -1.8 -1.9 -1.9 phosphotyrosine interaction domain containing 1
RTN1 -2.2 -1.9 -2.3 -2.0 -2.0 -2.0 -2.3 reticulon 1
  1. Values in italics are not significant.