Influence of Interleukin-10 -1082 promoter genotype in disease progression. A- Disease progression was calculated in months from the last surgery, reported as of December 2007. Differences between curves were significant (P = 0.04, Chi Square test). B- In vitro IL-10 secretion by patients' PBMC in response to LPS or PHA. Control PBMC (not stimulated) did not secrete IL-10. Culture supernatants were tested in triplicate by ELISA as described under methods. Lines represent median value in each case. Mann Whitney's test showed that differences between AA and AG/GG genotypes were not statistically significant. AA (PHA) vs AG/GG (PHA) P value: 0.6; AA (LPS) vs AG/GG (LPS) P value: 0.25.