Table 2 Comparison of Ex Vivo Metrics to Other Test Systems
From: Ex Vivo Metrics™, a preclinical tool in new drug development
Human Ex Vivo Metrics | Whole Animal | Animal Ex Vivo Perfusion | Organ Baths | Tissue Slices | Cells | Subcellular Systems | |
|---|---|---|---|---|---|---|---|
Relevance to target species | ● | - | - | ● | ● | ● | ● |
Physiologic functions | ● | ● | ● | - | - | - | - |
Nervous | ○ | ● | ○ | - | - | - | - |
Hormonal (relevant) | ● | ● | ● | ● | - | - | - |
Vasculature | ● | ● | ● | - | - | - | - |
Full cell complement | ● | ● | ● | ● | ● | - | - |
Extracellular matrix | ● | ● | ● | ● | ● | - | - |