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Table 6 Significant pathways at the nominal 0.005 level of the Hotelling T-square test *

From: Transcriptional patterns, biomarkers and pathways characterizing nasopharyngeal carcinoma of Southern China

Related Function Kegg Pathway Pathway description Number of genes p-value
Cell Growth & Death hsa04210 Apoptosis 9 1.20E-06
  hsa04110 Cell cycle 10 2.10E-06
Signal Transduction hsa04020 Calcium signaling pathway 13 1.80E-06
  hsa04010 MAPK signaling pathway 19 1.11E-05
  hsa04310 Wnt signaling pathway 10 1.24E-05
  hsa04630 Jak-STAT signaling pathway 7 3.64E-05
  hsa04070 Phosphatidylinositol signaling system 7 8.03E-05
  hsa04370 VEGF signaling pathway 5 0.000333
Immune System hsa04650 Natural killer cell mediated cytotoxicity 7 1.67E-05
  hsa04640 Hematopoietic cell lineage 6 2.63E-05
  hsa04662 B cell receptor signaling pathway 9 5.01E-05
  hsa04660 T cell receptor signaling pathway 6 5.06E-05
  hsa04664 Fc epsilon RI signaling pathway 7 9.76E-05
  hsa04610 Complement and coagulation cascades 5 0.0001297
  hsa04620 Toll-like receptor signaling pathway 5 0.003536
Signaling Molecules and Interaction hsa04080 Neuroactive ligand-receptor interaction 12 1.00E-07
  hsa04060 Cytokine-cytokine receptor interaction 15 3.00E-07
  hsa04514 Cell adhesion molecules (CAMs) 9 1.50E-05
  hsa04512 ECM-receptor interaction 8 0.0004294
Endocrine System hsa04910 Insulin signaling pathway 8 6.00E-06
  hsa04920 Adipocytokine signaling pathway 5 6.90E-06
  hsa03320 PPAR signaling pathway 6 3.42E-05
  hsa04912 GnRH signaling pathway 8 3.66E-05
Cell Communication hsa04510 Focal adhesion 17 9.20E-06
  hsa04520 Adherens junction 5 2.95E-05
  hsa04540 Gap junction 10 3.89E-05
  hsa04530 Tight junction 10 4.48E-05
Others hsa04810 Regulation of actin cytoskeleton 11 3.90E-06
  hsa00260 Glycine, serine and threonine metabolism 6 1.54E-05
  hsa00190 Oxidative phosphorylation 17 3.14E-05
  hsa00230 Purine metabolism 18 3.22E-05
  hsa00500 Starch and sucrose metabolism 9 7.68E-05
  hsa00980 Metabolism of xenobiotics by cytochrome P450 7 8.06E-05
  hsa00240 Pyrimidine metabolism 12 0.0001352
  hsa04730 Long-term depression 6 0.0002265
  hsa04720 Long-term potentiation 7 0.0003216
  hsa04360 Axon guidance 11 0.0007991
  1. * Significance threshold of permutation tests: 0.005
  2. Significance threshold of Hotelling's T-square tests: 0.005
  3. Number of principal components for Hotelling's T-square tests: 3
  4. Square tests: 3