Table 5 MILANO analysis for oncogenes and tumor suppressor genes
Gene symbol | Role1 | Fold difference2 (NPC/NP) | Description | Map Location |
|---|---|---|---|---|
MIF | Candidate oncogene | 10.72 | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | 22q11.23 |
BIRC5 | Oncogene | 6.62 | baculoviral IAP repeat-containing 5 (survivin) | 17q25 |
PTTG1 | Proto-oncogene | 7.35 | pituitary tumor-transforming 1 | 5q35.1 |
CCND2 | Proto-oncogene | 20.15 | cyclin D2 | 12p13 |
ATM | Tumor suppressor | 0.27 | ataxia telangiectasia mutated (includes complementation groups A, C and D) | 11q22-q23 |
FOXO1A | Tumor suppressor | 0.20 | forkhead box O1A (rhabdomyosarcoma) | 13q14.1 |
TGFBR2 | Tumor suppressor | 0.19 | transforming growth factor, beta receptor II | 3p22 |
PRKAR1A | Tumor suppressor | 0.17 | protein kinase, cAMP-dependent, regulatory, type I, alpha | 17q23-q24 |
KLF5 | Tumor suppressor | 0.17 | Kruppel-like factor 5 (intestinal) | 13q22.1 |
PDCD4 | Tumor suppressor | 0.10 | programmed cell death 4 (neoplastic transformation inhibitor) | 10q24 |