Suppression of morphine-6-glucuronide-induced licking in ferrets with Zangrado, and the effects of CB
receptor inhibition of AM 251. Ferrets treated with M6G display a licking response which was quantified. Treatment with Zangrado (3 mg/kg, ip) reduced this licking response by 87% (n = 6, P < 0.01). Co-treatment with AM 251, the CB1 receptor antagonist, failed to reverse the benefits of Zangrado on M6G-induced itch (n = 6).