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Table 3 Percentage of CMV-antigen specific interferon gamma producing CD4+ and CD8+ T-cells of R+ patients with or without concurrent CMV replication.

From: Cytomegalovirus-specific T-cell responses and viral replication in kidney transplant recipients

    CMV replicating
(n = 6/48)
CMV non-replicating
(n = 42/48)
p-values*
CMV- CD3+CD4+ median (range) 0.02 (0.00–0.38) 0.08 (0.00–4.35) 0.011
lysate (m = 79) CD3+CD8+ median (range) 0.01 (0.00–0.21) 0.02 (0.00–1.31) 0.189
pp72 CD3+CD4+ median (range) 0.04 (0.00–0.22) 0.04 (0.00–0.36) 0.291
peptides (m = 50) CD3+CD8+ median (range) 0.03 (0.00–0.24) 0.07 (0.00–0.68) 0.019
pp65 CD3+CD4+ median (range) 0.00 (0.00–0.14) 0.03 (0.00–0.50) < 0.001
peptides CD3+CD8+ median (range) 0.01 (0.00–0.21) 0.03 (0.00–0.62) 0.033
  1. Note. The results are given as frequencies of CD3+ CD4+ or CD3+CD8+ lymphocytes as detailed in Materials&Methods. The number of measurements exceeds the number of patients because some patients were tested at more than one visit. CMV, cytomegalovirus; R, recipient; n, number of patients; m, number of measurements. CMV seropositive KT patients included both D+R+ and D-R+ constellations. Mann-Whitney U test was used to calculate differences (*)