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Table 3 Percentage of CMV-antigen specific interferon gamma producing CD4+ and CD8+ T-cells of R+ patients with or without concurrent CMV replication.

From: Cytomegalovirus-specific T-cell responses and viral replication in kidney transplant recipients

   

CMV replicating

(n = 6/48)

CMV non-replicating

(n = 42/48)

p-values*

CMV-

CD3+CD4+

median (range)

0.02 (0.00–0.38)

0.08 (0.00–4.35)

0.011

lysate (m = 79)

CD3+CD8+

median (range)

0.01 (0.00–0.21)

0.02 (0.00–1.31)

0.189

pp72

CD3+CD4+

median (range)

0.04 (0.00–0.22)

0.04 (0.00–0.36)

0.291

peptides (m = 50)

CD3+CD8+

median (range)

0.03 (0.00–0.24)

0.07 (0.00–0.68)

0.019

pp65

CD3+CD4+

median (range)

0.00 (0.00–0.14)

0.03 (0.00–0.50)

< 0.001

peptides

CD3+CD8+

median (range)

0.01 (0.00–0.21)

0.03 (0.00–0.62)

0.033

  1. Note. The results are given as frequencies of CD3+ CD4+ or CD3+CD8+ lymphocytes as detailed in Materials&Methods. The number of measurements exceeds the number of patients because some patients were tested at more than one visit. CMV, cytomegalovirus; R, recipient; n, number of patients; m, number of measurements. CMV seropositive KT patients included both D+R+ and D-R+ constellations. Mann-Whitney U test was used to calculate differences (*)