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Table 1 Lethal Radiation Rescue in Mice for Early-acting Cytokines

From: Multilineage hematopoietic recovery with concomitant antitumor effects using low dose Interleukin-12 in myelosuppressed tumor-bearing mice

Cytokine Dose Dosing Schedule % Survival Reference
IL-1β 3000 ng single dose, -20 hr 100 (n = 10) 17
SCF 2000 ng -20 h, -2 h, +4 h 100 (n = 20) 18
TPO 300 ng single dose, +2 h 90 (n = 4–8)* 19
TPO 300 ng single dose, +2 h 70 (n = 20)** 19
IL-12 100 ng single dose, -24 h 91 (n = 38)*** 36
IL-12 100 ng single dose, +1 h 78 (n = 35)*** 36
  1. *radiation dose was 800 rad for C57BL/6 mice; **radiation dose was 900 rad for C57Bl/6; ***radiation dose was 1000 rad for C57BL/6 mice