Skip to main content

Table 1 Lethal Radiation Rescue in Mice for Early-acting Cytokines

From: Multilineage hematopoietic recovery with concomitant antitumor effects using low dose Interleukin-12 in myelosuppressed tumor-bearing mice

Cytokine

Dose

Dosing Schedule

% Survival

Reference

IL-1β

3000 ng

single dose, -20 hr

100 (n = 10)

17

SCF

2000 ng

-20 h, -2 h, +4 h

100 (n = 20)

18

TPO

300 ng

single dose, +2 h

90 (n = 4–8)*

19

TPO

300 ng

single dose, +2 h

70 (n = 20)**

19

IL-12

100 ng

single dose, -24 h

91 (n = 38)***

36

IL-12

100 ng

single dose, +1 h

78 (n = 35)***

36

  1. *radiation dose was 800 rad for C57BL/6 mice; **radiation dose was 900 rad for C57Bl/6; ***radiation dose was 1000 rad for C57BL/6 mice
Back to article page

Journal of Translational Medicine

ISSN: 1479-5876

Contact us