Figure 2

Red blood cell recovery profiles for vehicle, G-CSF, IL-12 pre-only, IL-12 post-only and IL-12 pre-post treatment groups following radiation (625 rad). Red blood cell recovery profiles are shown for the EL4 tumor model in (A) and the Lewis lung cancer model in (B). Pre-radiation blood values reflect an average of all animals in both groups (70 mice) before radiation and tumor inoculation. The normal threshold value for murine red blood cell counts is indicated. Following the initial dose of vehicle or cytokine, 4 subsequent doses were given every 3–4 days following radiation. IL-12 treated mice received a total dose (5 single doses) of 220 ng, whereas G-CSF treated mice received a total dose (5 single doses) of 5 μg.