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Table 2 Induction of Allogeneic T cell responses by DC modulating agents

From: Toll-like receptor activation enhances cell-mediated immunity induced by an antibody vaccine targeting human dendritic cells

DC Treatment

TLR specificity

No Vaccine S.I.

Plus Vaccine S.I.

None

 

-

-

+ LPS

4

4.1

4.0

+ Pam3CSK4

2

3.0

5.6

+ Flagellin

5

2.4

4.8

+ MALP-2

2, 6

3.0

5.6

+ Poly IC

3

  

(Fig. 2a-2b)

 

3.6

6.0

Fig. 2c

 

2.4

3.8

+ Loxoribine

7

1.25

4.0

+ R-848

7, 8

2.39

1.85

(Fig. 2c)

   

+ Poly IC + R-848

3, 7, 8

NT

1.95

(Fig. 2c)

   
  1. NT-not tested; Stimulation indices derived from allogeneicT cell responses in a standard 5-day 3H-TdR incorporation assay. Two donors were tested in Figure 2a & 2b and three donors were tested in Figure 2c.
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Journal of Translational Medicine

ISSN: 1479-5876

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