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Table 2 Induction of Allogeneic T cell responses by DC modulating agents

From: Toll-like receptor activation enhances cell-mediated immunity induced by an antibody vaccine targeting human dendritic cells

DC Treatment TLR specificity No Vaccine S.I. Plus Vaccine S.I.
None   - -
+ LPS 4 4.1 4.0
+ Pam3CSK4 2 3.0 5.6
+ Flagellin 5 2.4 4.8
+ MALP-2 2, 6 3.0 5.6
+ Poly IC 3   
(Fig. 2a-2b)   3.6 6.0
Fig. 2c   2.4 3.8
+ Loxoribine 7 1.25 4.0
+ R-848 7, 8 2.39 1.85
(Fig. 2c)    
+ Poly IC + R-848 3, 7, 8 NT 1.95
(Fig. 2c)    
  1. NT-not tested; Stimulation indices derived from allogeneicT cell responses in a standard 5-day 3H-TdR incorporation assay. Two donors were tested in Figure 2a & 2b and three donors were tested in Figure 2c.