Table 3 Comparison of changes in levels of soluble protein biomarkers (VEGF, sVEGFR-2, and sVEGFR-3) in patients with partial response (PR) vs. patients that did not achieve partial response (Non-PR). The sample size listed for each group in each case refers to the number of ratios to baseline represented within the different intervals.
| Â | Mean Fold Change | P value | |
|---|---|---|---|
PR (n) | Non-PR (n) | (t-test; rank sum) | |
VEGF | Â | Â | Â |
   All timepoints (cycles 1–3) | 5.22 (123) | 2.87 (122) | 0.0022; 0.035 |
   All day 28 timepoints (cycles 1–3) | 7.91 (74) | 3.94 (75) | 0.0005; 0.0001 |
sVEGFR-2 | Â | Â | Â |
   All timepoints (cycles 1–3) | -1.73 (123) | -1.57 (121) | 0.0082; 0.001 |
   All day 28 timepoints (cycles 1–3) | -2.12 (74) | -1.79 (75) | 0.0003; 0.0003 |
sVEGFR-3 | Â | Â | Â |
   All timepoints (cycles 1–3) | -1.63 (123) | -1.51 (123) | 0.108; 0.104 |
   All day 28 timepoints (cycles 1–3) | -2.17 (74) | -1.89 (76) | 0.010; 0.042 |